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Barrier film formation refers to the process by which a continuous film, typically made of a polymer or combination of polymers, is created to provide a physical barrier to moisture, gases, or chemicals on the surface of a substrate, protecting it from environmental exposure or controlling the release of active ingredients. In pharmaceutical sciences, such films are used to coat drugs to protect them from hydrolytic degradation or unwanted interactions with moisture[1]. In packaging, barrier films help prevent the passage of gases or moisture to extend shelf life[5][3]. The process depends on the chemical composition of the film-forming components, their interaction with plasticizers, and the conditions under which the film is formed, such as temperature and humidity[5][3]. Barrier film formation is a process property and not a molecular or therapeutic target, so its inclusion in a list of molecular drug targets or receptors is incorrect[1][5][3].
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