Target intelligence / Profile preview

Barrier Function of the Stratum Corneum

Molecular classification: Other (physiological barrier)

Overview

The stratum corneum is the outermost layer of the epidermis, providing a crucial barrier against external agents. It is composed of flattened corneocytes embedded in a lipid matrix, which together prevent water loss, protect against pathogens, and regulate permeability. Its integrity is essential for maintaining skin health, and dysfunction can lead to conditions like eczema and psoriasis.

Other names: Stratum Corneum Barrier Function

Mechanism of action

Enhancing lipid structure, maintaining hydration, and regulating pH.

Biological functions

Physical BarrierImmune BarrierPermeability Regulation

Disease associations

InflammationSkin Conditions

Safety considerations

Compromised barrier function can increase sensitivity to allergens and irritants

Interacting drugs

Various topical moisturizers and barrier repair creams

Biomarkers

Transepithelial Water Loss (TEWL)Lipid Composition

Beyond the preview

Go deeper on Barrier Function of the Stratum Corneum.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Barrier Function of the Stratum Corneum.

Explore the full profile