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Target intelligence / Profile preview
BARX1 antisense RNA 1 (BARX1-AS1)
- Target
- BARX1-AS1
- Molecular classification
- Other (long non-coding RNA, lncRNA)
01
Overview
BARX1 antisense RNA 1 (BARX1-AS1 or BARX1-DT) is a long non-coding RNA transcribed antisense to the BARX1 gene locus. It has no protein-coding potential but modulates biological processes, notably by regulating gene expression associated with proliferation, migration, and invasion in cancer cells. Elevated BARX1-DT expression is associated with poor prognosis in laryngeal squamous cell carcinoma and is used as part of lncRNA-based classifiers for patient stratification. Functional studies indicate that BARX1-DT promotes oncogenic properties in carcinoma cells, but there are currently no drugs that directly interact with this lncRNA or exploit it as a therapeutic target.
- Other names
- BARX1 divergent transcriptBARX1-DTBARX1 antisense RNA 1 (head to head)BARX1-AS1
02
Mechanism of action
No approved drugs directly target BARX1-AS1; its potential roles are modulatory, through influencing gene networks or microRNA activity
03
Biological functions
Regulation of gene expressionModulation of cell proliferationCell migration and invasion (in cancer cells)
04
Disease associations
Cancer (notably laryngeal squamous cell carcinoma [LSCC] and suggested in other carcinomas)
05
Biomarkers
Prognostic biomarker in laryngeal squamous cell carcinoma (LSCC), as part of lncRNA panels to stratify patient risk and predict immune response to immunotherapy
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