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Target intelligence / Profile preview
Basigin (BSG)
- Target
- BSG
- Molecular classification
- Immunoglobulin superfamily, Type I transmembrane protein
01
Overview
Basigin, also known as CD147 or EMMPRIN, is a highly glycosylated type I transmembrane protein belonging to the immunoglobulin superfamily. It plays diverse roles in normal physiology, including spermatogenesis, embryo implantation, neural development, and cone photoreceptor survival. It is also involved in various disease states, such as cancer metastasis, malaria, and HIV infection, making it a potential therapeutic target.
- Other names
- CD147EMMPRIN (Extracellular Matrix Metalloproteinase Inducer)Ok blood group antigen
02
Mechanism of action
Not applicable; Basigin is a target itself, not a drug.
03
Biological functions
SpermatogenesisEmbryo implantationNeural network formationCone photoreceptor survivalMonocarboxylate transporter localizationNutrient transportCell adhesionInflammatory signalingSignal transduction
04
Disease associations
Cancer metastasisTumor invasionMalariaHIV infectionInflammatory disordersRetinal defects
05
Safety considerations
Potential for off-target effects due to widespread expression.
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