Basigin receptor (CD147 (EMMPRIN))

Basigin receptor (CD147, also known as EMMPRIN) is a widely expressed transmembrane glycoprotein of the immunoglobulin superfamily that acts as a receptor for several ligands, including cyclophilins, and supports the activity of monocarboxylate transporters. It is a key inducer of matrix metalloproteinase expression, promoting extracellular matrix remodeling, inflammation, and tumor progression. Basigin plays important physiological roles in vision, fertilization, and neural development, while pathological upregulation is implicated in cancer metastasis, cardiovascular diseases, infection by malaria parasites, and inflammatory conditions. The high degree of post-translational glycosylation critically regulates both its normal and disease-associated functions[1][2][3][4][5].

Other names

extracellular matrix metalloproteinase inducerEMMPRINcluster of differentiation 147BSGOka blood group antigenTCSF (tumor cell-derived collagenase stimulatory factor)neurothelinGP42HAb18Gleucocyte activation-associated antigen M6HT7CE9OX-47

Inhibition of CD147 blocks ligand binding (e.g., cyclophilins), suppresses downstream signaling (e.g., TRAF2-TAK1 pathway), and reduces MMP induction Antibody binding blocks receptor–ligand or protein–protein interactions Modulation of glycosylation disrupts receptor function and disease-associated signaling