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Target intelligence / Profile preview
Basophil
- Molecular classification
- Leukocyte, Granulocyte, Immune cell
01
Overview
Basophils are a type of granulocyte leukocyte involved in inflammatory and immune responses, particularly in allergic reactions and parasitic infections. They release mediators such as histamine and cytokines like IL-4 and IL-13, contributing to vasodilation, increased vascular permeability, and Th2-type immune responses. While not typically considered a direct therapeutic target, their activity is modulated by drugs targeting allergic pathways.
02
Mechanism of action
N/A
03
Biological functions
Innate immunityAdaptive immunityInflammationDefense against parasitesRelease of inflammatory mediatorsCytokine secretion
04
Disease associations
Allergic reactionsAsthmaParasitic infectionsUrticariaPotential role in autoimmune diseasesPotential role in cancer (immune surveillance)
05
Safety considerations
Excessive basophil activation can lead to severe allergic reactions (anaphylaxis)Basophilia can indicate underlying hematological malignancies or inflammatory conditions
06
Interacting drugs
Antihistamines
2 more in the full profile.
07
Biomarkers
Basophil countBasophil activation markers (e.g., CD63)
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