Basophil granulocyte (Basophil)

Basophils are a rare subtype of white blood cell classified as granulocytes. They make up less than 1% of circulating leukocytes but are the largest among the granulocytes. Their primary functions include mediating inflammatory responses—particularly those associated with allergies—and defending against parasites. Basophils contain granules rich in histamine and heparin; upon activation by allergens or pathogens, they release these substances to promote vasodilation and prevent blood clotting. They also secrete cytokines such as IL‑4 that help orchestrate immune responses[1][3][7]. Unlike mast cells—which reside in tissues—basophils circulate in the bloodstream. Abnormal levels may indicate underlying conditions such as chronic myeloid leukemia or other myeloproliferative disorders[4]. While therapies targeting basophils are being explored for allergic and autoimmune diseases, "basophil granulocyte" is not itself a molecular therapeutic target like a receptor or enzyme but rather refers to an entire cell type[6]. **Note:** The entry "Basophil granulocyte" is not a canonical molecular target such as a receptor or enzyme; it refers to an entire cell population rather than a single molecule suitable for direct drug targeting. Therefore, this entry is considered incorrect if used where only molecular targets should be listed.

Other names

Basophilbasophilebasophilic granulocytegranular leukocyte (basophilic type)