Basophil Histamine Release (BHR)

Basophil histamine release refers to the process by which basophils, a type of white blood cell, secrete histamine in response to various stimuli. This release is a key event in allergic reactions and immune responses, contributing to inflammation and other physiological effects. The classic trigger is cross-linking of IgE antibodies bound to FcεRI receptors by specific antigens. Other triggers include calcium ionophores and platelet-derived factors. The process can be modulated by intracellular signaling pathways, and dysregulation contributes directly to symptoms seen in allergic rhinitis, asthma exacerbations, urticaria, anaphylaxis, and other hypersensitivity disorders.

Other names

Basophil degranulationHistamine secretion from basophilsIgE-mediated basophil activation

N/A (This is a process, not a target)