Target intelligence / Profile preview

Battenin (CLN3)

Target: CLN3
Molecular classification: Transmembrane protein, Atypical solute carrier (SLC) transporter, Transporter (TCDB)

Overview

Battenin/CLN3 is a multi-pass transmembrane protein crucial for proper lysosomal/endosomal function. Its deficiency causes juvenile-onset neurodegenerative disease marked by vision loss and neurological decline.

Other names: BTN1BTSJNCL proteinceroid-lipofuscinosis neuronal 3 protein

Biological functions

Lysosomal functionMicrotubule-dependent anterograde transportIntracellular traffickingCellular waste processingRecycling

Disease associations

Juvenile neuronal ceroid lipofuscinosis (JNCL)Batten diseaseNeurodegenerative disease

Safety considerations

Progressive vision lossSeizuresMovement disordersCognitive regressionEarly death due to progressive organ failure

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