Target intelligence / Profile preview

Bcl-2-associated agonist of cell death (BAD)

Target: BAD
Molecular classification: Other (Protein involved in apoptosis regulation)

Overview

The Bcl-2-associated agonist of cell death (BAD) is a pro-apoptotic protein belonging to the Bcl-2 family. It plays a crucial role in regulating apoptosis by interacting with anti-apoptotic members of the Bcl-2 family, such as Bcl-2 and Bcl-xL. BAD's activity is modulated through phosphorylation, which affects its ability to induce cell death. It is involved in various diseases, including cancer and neurodegenerative conditions[1][5][7].

Other names: Bcl-2-binding component 6Bcl-2-like protein 8

Biological functions

ApoptosisCell death

Disease associations

CancerNeurodegenerative disease

Safety considerations

Dysregulation of BAD can contribute to diseases like cancer and neurodegenerative disorders.

Interacting drugs

ABT-737

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