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Bcl-2-associated X protein (Bax)

Target: Bax
Molecular classification: Bcl-2 family protein

Overview

Bax is a pro-apoptotic member of the Bcl-2 protein family. It promotes apoptosis by permeabilizing the mitochondrial outer membrane, leading to the release of cytochrome c and activation of downstream caspases. It is a key regulator of the intrinsic apoptosis pathway.

Mechanism of action

Promotes mitochondrial outer membrane permeabilization, leading to cytochrome c release and caspase activation.

Biological functions

ApoptosisMitochondrial outer membrane permeabilization (MOMP)Regulation of cell death

Disease associations

CancerNeurodegenerative disease

Safety considerations

Overactivation or dysregulation can lead to excessive cell death.

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