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Bcl-2 family proteins and downstream apoptotic pathway (N/A)

Target: N/A
Molecular classification: Protein family, Enzyme, Apoptotic factors, Protease

Overview

The mitochondrial pathway of apoptosis is a key regulator of programmed cell death. It is primarily regulated by the Bcl-2 family of proteins. Pro-apoptotic signals trigger MOMP, releasing cytochrome c and other apoptogenic factors, leading to caspase activation and cellular dismantling. Lactaptin and its recombinant form RL2 induce apoptosis through this pathway by downregulating Bcl-2 and activating caspases. This pathway is independent of p53 status, making it attractive for targeting p53-deficient tumors.

Other names: Mitochondrial apoptosis pathwayIntrinsic apoptosis pathwayBcl-2BaxBakCytochrome cAPAF1Caspase-9Caspases (-3/-7)

Mechanism of action

Downregulation/depletion of Bcl-2; activation of caspases; induction of MOMP

Biological functions

ApoptosisCell deathRegulation of apoptosisMitochondrial outer membrane permeabilizationCaspase activation

Disease associations

CancerDrug resistanceNeurodegenerative disease

Safety considerations

Off-target effects on normal cellsPotential for inducing unwanted apoptosis

Interacting drugs

Lactaptin

2 more in the full profile.

Biomarkers

Bcl-2 expression levelsBax expression levelsCaspase activation

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