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Target intelligence / Profile preview
BCL2-like protein 11 (BIM)
- Target
- BIM
- Molecular classification
- BH3-only protein, BCL-2 family protein, Apoptosis regulator
01
Overview
Bcl-2-like protein 11 (BIM) is a pro-apoptotic member of the BCL-2 family. It plays a critical role in regulating apoptosis, particularly as an initiator of programmed cell death in various tissues. BIM acts as an apoptotic activator by interacting with anti-apoptotic proteins, promoting mitochondrial outer membrane permeabilization, and activating caspases leading to cell death. Altered expression or function of BIM has been implicated in cancer resistance mechanisms.
- Other names
- Bcl-2-like protein 11BCL2L11
02
Mechanism of action
BIM acts as an apoptotic activator by interacting with anti-apoptotic proteins such as BCL2, BCL-X(L)/BCL2L1, and MCL1. Through these interactions, it promotes mitochondrial outer membrane permeabilization and subsequent activation of caspases leading to cell death
03
Biological functions
ApoptosisCell deathNegative selection of thymocytes
04
Disease associations
CancerResistance to chemotherapyTumor progressionMetastasis
05
Safety considerations
Inducing apoptosis in healthy cells
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