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BCL1 tumor cells (BCL1)

Target: BCL1
Molecular classification: Other

Overview

BCL1 tumor cells refer to a transplantable murine B-cell leukemia cell line (BCL1, RRID:CVCL_0166) established from a spontaneous lymphoma in a female BALB/c mouse, serving as a model for human prolymphocytic leukemia (PLL). In syngeneic mice, injection leads to massively enlarged spleens followed by leukemia, with strong dependence on host lymphoid tissue microenvironment; splenectomy alters growth kinetics, delaying leukemia onset and shifting infiltration to lymph nodes. Note: "BCL1" is sometimes confused with the CCND1 gene (cyclin D1, alias BCL1), a cell cycle regulator and therapeutic target in mantle cell lymphoma via t(11;14) translocation, but the query specifies "BCL1 tumor cells," identifying the cell line, not the gene/protein.

Other names: BCL-1BCL 1BCL1 clone 5B1b

Disease associations

LeukemiaProlymphocytic leukemia

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