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Target intelligence / Profile preview
B-cell CLL/lymphoma 11A (BCL11A)
- Target
- BCL11A
- Molecular classification
- Transcription factor, Proto-oncogene, C2H2-type zinc-finger DNA-binding protein
01
Overview
BCL11A is a gene encoding a regulatory protein that functions as a transcription factor. It plays critical roles in hematopoiesis, brain development, and fetal-to-adult hemoglobin switching. It is considered a proto-oncogene and is implicated in leukemia and lymphoma. Therapeutic targeting of BCL11A is under investigation for treating sickle cell disease and beta-thalassemia.
- Other names
- BCL11 transcription factor A
02
Mechanism of action
Targeting BCL11A to reactivate fetal hemoglobin
03
Biological functions
Transcriptional regulationHematopoietic system developmentBrain developmentFetal-to-adult hemoglobin switchingGene repressionCell differentiationRegulation of apoptosis
04
Disease associations
LeukemiaLymphomaβ-Hemoglobinopathies (Sickle cell disease, Beta-thalassemia)Intellectual Disability SyndromesAutism Spectrum DisorderType II Diabetes
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