B-cell lymphoma 2 protein (BCL2)

B-cell lymphoma 2 protein (Bcl‑2) is an integral outer mitochondrial membrane protein encoded by the BCL2 gene. It is a founding member of the family of proteins that regulate apoptosis. The primary function of Bcl‑2 is to block programmed cell death by controlling mitochondrial membrane permeability and inhibiting pro-apoptotic factors. Overexpression or chromosomal translocation involving this gene—especially t(14;18) with immunoglobulin heavy chain locus—is implicated in various cancers such as follicular lymphoma and other malignancies. Its anti-apoptotic action contributes both to tumorigenesis and resistance to therapy. Drugs targeting this pathway aim to restore normal apoptotic processes in diseased cells[1][5][2]. The query refers specifically to "B-cell lymphoma 2 protein mRNA." This term describes the messenger RNA encoding for the B-cell lymphoma 2 protein, not a therapeutic target itself but rather a nucleic acid intermediate. The actual therapeutic target is the protein product (Bcl‑2), not its mRNA transcript. Therefore, is_incorrect should be set as true, because "B-cell lymphoma 2 protein mRNA" refers incorrectly to an mRNA rather than directly naming a canonical druggable target; it should be standardized as "B-cell lymphoma 2 protein" (abbreviation: "BCL2")[1][5].

Other names

Bcl-2BCL2 apoptosis regulatorB-cell leukemia/lymphoma 2 protein

Inhibition of anti-apoptotic activity to restore programmed cell death in malignant cells[1][5]