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BCL2-like protein 2 (Bcl-w)

Target: Bcl-w
Molecular classification: Bcl-2 family protein, Anti-apoptotic protein

Overview

Bcl-w (BCL2-like protein 2) is an anti-apoptotic member of the Bcl-2 protein family, crucial for regulating cell survival and inhibiting apoptosis under stress conditions. It functions by controlling mitochondrial membrane permeability, preventing the release of pro-apoptotic factors. Dysregulation of Bcl-w has been implicated in cancer development due to its role in evading programmed cell death. It is essential for spermatogenesis and neuronal health.

Other names: BCLWPPP1R51BCL2-L-2

Mechanism of action

Inhibition of apoptosis by preventing the release of pro-apoptotic factors from the mitochondria.

Biological functions

Inhibition of apoptosisRegulation of mitochondrial membrane permeabilityCell survival

Disease associations

CancerSpermatogenesis disorders

Safety considerations

Inhibition of apoptosis may promote cancer development or resistance to therapy.

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