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BCLAF1 and THRAP3 family member 3 (BCLAF3)
- Target
- BCLAF3
- Molecular classification
- Transcription coregulator, DNA-binding protein, Member of the THRAP3/BCLAF1 protein family
01
Overview
BCLAF1 and THRAP3 family member 3 (abbreviated BCLAF3) is a human protein-coding gene that, based on current annotations, is predicted to act as a DNA-binding protein and transcriptional coregulator[3][5][6]. It is a member of the THRAP3/BCLAF1 protein family, which is characterized by DNA binding and involvement in transcriptional regulation. While homologous proteins in this family (THRAP3 and BCLAF1) are well-established in RNA splicing, DNA damage response, and cancer biology[1][2][4], detailed functional and disease-specific studies on BCLAF3 itself are limited. No drug interactions or biomarker uses are currently described for BCLAF3, and it is not presently considered a therapeutic target. The protein is 711 amino acids in length in the human genome[5].
- Other names
- BCLAF3
02
Biological functions
Transcriptional regulation (positive regulation of transcription by RNA polymerase II)DNA binding
03
Disease associations
Other (no direct evidence of cancer, inflammation, or other major disease associations found in current sources for BCLAF3 itself; however, close family members like THRAP3 and BCLAF1 have known roles in DNA damage response and cancer)
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