Molecular Classification
Autophagy protein, Scaffolding protein, PI3K complex component
Other Names
ATG6, VPS30, beclin 1, autophagy related
Disease Roles
CancerNeurodegenerative diseaseSchizophrenia

Beclin-1 Overview

Beclin-1 (BECN1) is a key regulatory protein in autophagy, acting as a scaffold within Class III PI3K complexes. It regulates autophagosome nucleation and modulates crosstalk between apoptosis and survival pathways. Altered expression or mutation/deletion of BECN1 has been implicated in several diseases, including cancer and neurodegeneration.

Mechanism of Action

Enhances Beclin-1 mediated autophagy and neuroprotection through increased induction/stabilization mechanisms.

Biological Functions

Autophagy
Mitophagy
Apoptosis regulation
Membrane trafficking
Tumor suppression
Regulation of cell death

Disease Associations

Cancer
Neurodegenerative disease
Schizophrenia

Safety Considerations

  • Potential for off-target effects on other autophagy-related pathways
  • Complex role in cell survival and death pathways requires careful consideration of context-dependent effects

Interacting Drugs

Trehalose

Associated Biomarkers

Biomarker
Beclin-1 expression levels in tumor tissue
Beclin-1 levels in hippocampus of schizophrenia patients