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Target intelligence / Profile preview
BEN domain-containing protein 5 (BEND5)
- Target
- BEND5
- Molecular classification
- Transcription factor, Chromatin boundary factor
01
Overview
BEN domain-containing protein 5 (BEND5) is a sequence-specific transcriptional repressor that possesses a BEN domain, enabling direct DNA binding to defined motifs. BEND5 serves as a chromatin boundary factor and negatively regulates DNA-templated transcription. It is particularly implicated in neurogenesis and early germ cell differentiation, functioning by demarcating chromatin boundaries and promoting the transition of pluripotent cells toward specific developmental fates. Aberrant expression of BEND5 has been associated with pathologic tissue states (such as arachnoid cysts) and chromosomal rearrangements, including a role as a fusion partner in BEND5–ALK fusions found in pediatric cancers, suggesting a possible but as yet unexploited disease association. BEND5 is not currently considered a direct therapeutic target, and no drugs are known to interact with it[1][2][3][4][5].
- Other names
- C1orf165FLJ11588BEN domain containing 5BEN domain-containing protein 5BEND5
02
Biological functions
Negative regulation of DNA-templated transcriptionSequence-specific DNA bindingChromatin boundary markingRegulation of neurogenesisRegulation of early germ cell differentiation
03
Disease associations
Cancer (e.g., BEND5–ALK fusion in pediatric cancer)Potential roles in other pathological tissue states (e.g., arachnoid cysts)
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