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Target intelligence / Profile preview
BEN domain-containing protein 6 (BEND6)
- Target
- BEND6
- Molecular classification
- BEN domain-containing protein, Transcription factor, Transcription corepressor
01
Overview
BEN domain-containing protein 6 (BEND6) is a nuclear co-repressor that binds the CSL transcription factor (CBF1/RBPJ) and antagonizes Notch-dependent gene activation, thereby inhibiting Notch-mediated self-renewal and promoting neural differentiation. It acts analogously to the *Drosophila* Insensitive protein as a BEN-solo factor regulating neural cell fate, and is thought to fine-tune Notch signaling during embryonic brain development. BEND6 is predicted to act within the nucleus, regulating chromatin and gene expression relevant to neural stem cell differentiation. Diseases associated include Carpenter syndrome 1, and while it modulates pathways central to neurodevelopment, it is not currently known to be a direct target of approved drugs[1][2][3][4][5].
- Other names
- BEND6C6orf65FLJ30162bA203B9.1BEN domain containing 6BA203B9.1BEND6_HUMAN
02
Biological functions
Negative regulation of Notch signaling pathwayPromotion of neuron differentiationInhibition of neural stem cell self-renewalChromatin binding
03
Disease associations
Associated with Carpenter syndrome 1Potential modifier of neurodevelopmental disorders (Notch signaling and NSC fate)
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