Target intelligence / Profile preview

Bet v 1 allergen (Bet v 1)

Target: Bet v 1
Molecular classification: Pathogenesis-related class 10 (PR-10) protein, Allergen

Overview

Bet v 1 is the major allergen found in birch pollen. It is a PR-10 protein involved in plant defense and capable of binding various ligands. It triggers type I allergic reactions, leading to hay fever, asthma, dermatitis, and oral allergy syndrome due to cross-reactivity with homologous proteins in certain foods. Its allergenic potential is influenced by isoform type and ligand-binding state (e.g., iron).

Other names: Bet v 1.0101Bet v 1.0201Bet v 1.0102PR-10 protein

Biological functions

Plant defenseLigand bindingImmune modulation

Disease associations

AllergyHay feverAsthmaDermatitisOral Allergy Syndrome

Safety considerations

Cross-reactivity with food allergensPotential for anaphylaxis

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