Bet1 Golgi vesicular membrane trafficking protein (BET1)

Bet1 Golgi vesicular membrane trafficking protein (BET1) is a SNARE family membrane protein required for vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex[2][3][5]. BET1 contributes to docking and fusion of ER-derived vesicles with the cis-Golgi membrane and forms part of the multi-protein SNARE complex essential for this process. Mutations in the BET1 gene disrupt intracellular trafficking, and have been shown to cause severe congenital muscular dystrophy and epilepsy, highlighting its relevance in normal secretory pathway functioning and protein glycosylation. BET1 interacts with proteins including Syntaxin-5, SEC22b, GOSR2, and also with ERGIC-53, the latter of which is important for correct protein localization. BET1 is not a current therapeutic target or drug receptor, but defects in its function can cause human disease due to impaired vesicular trafficking[1][2][3][5].

Other names

BET1 homologhBET1Golgi vesicular membrane-trafficking protein p18Bet1p homologHBET1MDRPblocked early in transport 1 homolog

Not applicable; there are currently no drugs known to directly target this protein