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Beta-(1→3)-D-glucan synthase
- Molecular classification
- Enzyme, Glycosyltransferase, GT48 family, GT2 family
01
Overview
Beta-(1→3)-D-glucan synthase is a membrane-bound enzyme complex that catalyzes the synthesis of β(1→3)-D-glucan, a major structural polysaccharide in the fungal cell wall. This enzyme uses uridine diphosphate glucose (UDP-Glc) as the sugar donor to form β(1→3) glycosidic linkages. It is a validated pharmacological target for antifungal drugs. Inhibition leads to rapid loss of osmotic stability in pathogenic fungi.
- Other names
- GS-IIparamylon synthetasecallose synthase
02
Mechanism of action
Inhibition of β(1→3)-D-glucan synthesis
03
Biological functions
Cell wall biosynthesisPolysaccharide synthesisCell structure maintenance
04
Disease associations
InfectionFungal infections
05
Safety considerations
Development of resistance through mutations in FKS genes
06
Interacting drugs
Caspofungin
3 more in the full profile.
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