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Beta-(1→3)-glucan synthase (None)
- Target
- None
- Molecular classification
- Enzyme, Glycosyltransferase, GT48
01
Overview
Beta-glucan synthase is a membrane-bound glycosyltransferase enzyme complex responsible for the synthesis of β-glucans, essential polysaccharide components of fungal and some plant cell walls. In fungi, the most studied form is 1,3-β-glucan synthase, which catalyzes the formation of linear 1,3-β-D-glucan chains from UDP-glucose. This enzyme is a critical target for antifungal drugs due to its central role in maintaining cell wall integrity.
- Other names
- GS-II (glucosyl transferase II)Paramylon synthetaseCallose synthase1,3-β-D-glucan synthase
02
Mechanism of action
Inhibition of beta-(1→3)-glucan synthesis
03
Biological functions
Synthesis of β-glucansCell wall biosynthesisStructural component of fungal cell wall
04
Disease associations
Infection
05
Safety considerations
Development of resistance in fungiPotential for drug-drug interactions with antifungals
06
Interacting drugs
Caspofungin
3 more in the full profile.
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