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Target intelligence / Profile preview
Beta-1,3-galactosyltransferase 4 (B3GALT4)
- Target
- B3GALT4
- Molecular classification
- Enzyme
01
Overview
Beta-1,3-galactosyltransferase 4 is an enzyme involved in the biosynthesis of glycosphingolipids, particularly gangliosides, and in the modification of GPI-anchors. It plays a role in cell proliferation and migration, and its overexpression has been linked to breast cancer progression. The enzyme is also implicated in regulating autophagy through the AKT/mTOR pathway.
- Other names
- Beta3Gal-T4Beta3GalT4GALT2GALT4UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase 4Ganglioside galactosyltransferase
02
Mechanism of action
Catalyzes the transfer of galactose to N-acetylgalactosamine residues in glycosphingolipids; Blocks autophagy via the AKT/mTOR pathway
03
Biological functions
Glycosphingolipid biosynthesisGPI-anchor modificationAutophagy regulationCell proliferation and migration
04
Disease associations
Cancer (especially breast cancer)Malignancy progression
05
Biomarkers
Potential biomarker for breast cancer prognosis
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