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Target intelligence / Profile preview
Beta-2 Adrenoreceptor (ADRB2)
- Target
- ADRB2
- Molecular classification
- GPCR, G protein-coupled receptor, Rhodopsin family/class A
01
Overview
The beta-2 adrenoreceptor (β₂-adrenoceptor), also known as the beta-2 adrenergic receptor or ADRB2, is a G protein-coupled receptor (GPCR) that primarily binds epinephrine (adrenaline) and to a lesser extent norepinephrine. It plays a crucial role in mediating physiological responses such as smooth muscle relaxation and bronchodilation through the activation of adenylate cyclase and increased cyclic AMP (cAMP) levels via Gs proteins. Polymorphisms or mutations in this gene are associated with conditions like nocturnal asthma, obesity, and type 2 diabetes.
- Other names
- Beta-2 Adrenergic Receptorβ₂-adrenoceptorBeta-2 adrenoceptorBeta-adrenergic receptorB₂ARADRB₂R
02
Mechanism of action
Activation leads to stimulation of adenylate cyclase via Gs proteins, increasing cAMP levels.
03
Biological functions
Signal transductionSmooth muscle relaxationBronchodilationVasodilationUterine relaxationMetabolic regulation
04
Disease associations
AsthmaChronic obstructive pulmonary diseaseConduction disorderPreterm labour/deliverySleep-related breathing disorderObesityType 2 diabetes
05
Safety considerations
Clinical effects of some β-blockers may be mediated partly through β₂ antagonism even if not directly targeted for this use.Genetic polymorphisms affecting receptor function or expression can contribute to diseases such as obesity and type 2 diabetes.
06
Interacting drugs
Epinephrine
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