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Target intelligence / Profile preview
Beta-2-glycoprotein I (β₂GPI)
- Target
- β₂GPI
- Molecular classification
- Glycoprotein, Apolipoprotein
01
Overview
Beta-2-glycoprotein I (β₂GPI), also known as Apolipoprotein H (Apo-H), is a multifunctional plasma glycoprotein primarily recognized for its role in the immune system and coagulation pathways. It is the main autoantigen in antiphospholipid syndrome (APS), an autoimmune disorder characterized by thrombosis and pregnancy morbidity. β₂GPI regulates complement and coagulation, binds to negatively charged phospholipids, and modulates platelet aggregation. Anti-beta-2-glycoprotein I antibodies are used diagnostically for APS.
- Other names
- Apolipoprotein HApo-HBeta-2-glycoprotein 1
02
Mechanism of action
N/A
03
Biological functions
Regulation of complement activationRegulation of coagulationPhospholipid bindingPlatelet aggregation modulationImmune response modulation
04
Disease associations
Antiphospholipid syndrome (APS)ThrombosisPregnancy morbidityAutoimmune disorders
05
Safety considerations
Thromboembolic eventsRecurrent miscarriages
06
Biomarkers
Anti-beta-2-glycoprotein I antibodies
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