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Target intelligence / Profile preview
Beta-amyloid Aggregation
- Molecular classification
- Protein aggregation, Peptide aggregation
01
Overview
Beta-amyloid (Aβ) aggregation refers to the process by which amyloid-beta peptides misfold and self-associate into soluble oligomers, fibrils, and insoluble plaques. This aggregation is a central event in the pathogenesis of Alzheimer’s disease (AD). The process involves a conformational change to β-sheet-rich structures, followed by nucleation-dependent polymerization. Aggregated Aβ impairs cell-to-cell communication, stimulates immune responses, and results in neuronal death. The toxic species are believed to be soluble oligomers.
- Other names
- Amyloid-beta aggregationAβ aggregationAmyloid plaque formation
02
Mechanism of action
Inhibition of beta-amyloid aggregation, promotion of beta-amyloid clearance
03
Biological functions
Protein misfoldingSelf-assemblyNeurotoxicityImmune response stimulationImpaired cell-to-cell communication
04
Disease associations
Alzheimer's diseaseCerebral amyloid angiopathyNeurodegenerative disease
05
Safety considerations
Amyloid-related imaging abnormalities (ARIA)Potential for off-target effectsLack of clinical efficacy in some trials
06
Biomarkers
Cerebrospinal fluid Aβ42 levelsPET imaging of amyloid plaquesPlasma Aβ42/Aβ40 ratio
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