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Target intelligence / Profile preview
Beta Amyloid Peptide (Aβ)
- Target
- Aβ
- Molecular classification
- Peptide, Protein fragment
01
Overview
Beta amyloid peptide (Aβ) is a short peptide, typically 36–43 amino acids in length, generated by the proteolytic cleavage of the amyloid precursor protein (APP) via sequential action of β-secretase and γ-secretase enzymes. The most common isoforms are Aβ40 and Aβ42, with Aβ42 being more prone to aggregation and neurotoxicity. It is a major component of amyloid plaques in Alzheimer's disease and a key target for therapeutic interventions.
- Other names
- Amyloid-beta peptideAbetaβ-Amyloid
02
Mechanism of action
Target of drugs aiming to reduce production (β-secretase and γ-secretase inhibitors), aggregation, or promote clearance.
03
Biological functions
Unknown physiological functionsAggregation and plaque formationNeurotoxicity (oligomeric forms)
04
Disease associations
Alzheimer's diseaseCerebrovascular lesions
05
Safety considerations
β-secretase and γ-secretase inhibitors have shown limited efficacy and potential side effects in clinical trials.Anti-amyloid antibodies can cause amyloid-related imaging abnormalities (ARIA).
06
Biomarkers
Aβ40 levelsAβ42 levelsAβ42/Aβ40 ratioAmyloid plaques (imaging)
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