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Target intelligence / Profile preview
Beta-amyloid Peptide Aggregation (Aβ Aggregation)
- Target
- Aβ Aggregation
- Molecular classification
- Peptide aggregate, Protein aggregate
01
Overview
Beta-amyloid (Aβ) peptide aggregation refers to the process by which Aβ peptides self-associate into ordered oligomers and fibrillar structures. These aggregates are the principal component of amyloid plaques found in the brains of individuals with Alzheimer’s disease (AD), and their accumulation is a hallmark of this neurodegenerative disorder. Targeting this aggregation is a major therapeutic strategy under investigation for Alzheimer’s disease.
- Other names
- Amyloid-beta aggregationAbeta aggregationBeta-amyloid oligomerizationAmyloid plaque formation
02
Mechanism of action
Inhibition of nucleation, stabilization of non-toxic conformers/monomers, disruption of existing aggregates/fibrils, modulation of APP processing pathways
03
Biological functions
NeurotoxicitySynaptic dysfunctionInflammationAmyloid plaque formation
04
Disease associations
Alzheimer's diseaseNeurodegenerative disease
05
Safety considerations
Non-selective targeting of Aβ formsInflammation induced by aggregate disruptionOff-target effects of APP processing modulators
06
Biomarkers
Aβ40 levelsAβ42 levelsAmyloid plaque load (imaging)
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