Target intelligence / Profile preview

Beta-amyrin synthase (Medicago truncatula) (BAS)

Target: BAS
Molecular classification: Enzyme, Oxidosqualene cyclase

Overview

Other names: MT023$eta$-AS2,3-oxidosqualene cyclase

Mechanism of action

In the context of Diamond-Blackfan Anemia, MT-023 acts as a phenothiazine derivative to rescue ribosomal stress phenotypes; in plant biology, MT023 is the enzyme itself.

Biological functions

Triterpene biosynthesisSaponin synthesisPlant defense response

Disease associations

Diamond-Blackfan Anemia (as a drug candidate code MT-023)Liver disease (as a peptide code for ABCB4/MDR3)

Safety considerations

Off-target dopaminergic effectsCalmodulin antagonismEcotoxicity (for plant-related compounds)

Interacting drugs

MT-023 (Phenothiazine derivative)

1 more in the full profile.

Biomarkers

Saponin levelsp21 expression (in DBA models)

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