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Target intelligence / Profile preview
Beta-arrestin (ARRB)
- Target
- ARRB
- Molecular classification
- Scaffolding protein, Adaptor protein, Signaling protein
01
Overview
Beta-arrestins are a family of multifunctional intracellular proteins that regulate cellular signaling, particularly through interactions with G protein-coupled receptors (GPCRs). They play a crucial role in GPCR desensitization, internalization, and signaling through G protein-independent pathways. They serve as scaffolds connecting GPCRs to various downstream signaling pathways.
- Other names
- Beta-arrestin 1ARRB1Arrestin-2Beta-arrestin 2ARRB2Arrestin-3
02
Mechanism of action
Beta-arrestins regulate GPCR signaling by binding to activated and phosphorylated receptors, preventing G protein coupling and initiating receptor internalization and downstream signaling cascades.
03
Biological functions
GPCR desensitizationReceptor internalizationSignal transductionEndocytosis adapterG protein-independent signaling
04
Disease associations
CancerImmune disordersNeurological disordersMetabolic disorders
05
Safety considerations
Potential for off-target effects due to broad expression and diverse functions.Modulation of multiple signaling pathways may lead to unpredictable outcomes.
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