Arrestin beta-1 (ARRB1)

Arrestin beta-1 (ARRB1) is a multifunctional adaptor protein that regulates G protein-coupled receptor (GPCR) signaling by promoting receptor desensitization and internalization following ligand activation[1][2][3][4][5]. Beyond this canonical role, ARRB1 acts as a scaffold for a variety of intracellular signaling pathways, mediating both G protein-dependent and independent signaling, and is involved in diverse cellular functions including cell proliferation, metabolism, cytoskeletal organization, gene transcription, and epigenetic regulation[2][3]. ARRB1 is widely expressed in the central nervous system and immune cells and is implicated in the pathogenesis of diseases such as cancer, neurodegenerative disorders, and cardiovascular disease; its activity modulates key pathways through interactions with enzymes, kinases, transcription factors, and epigenetic regulators[3][1][2][4][5].

Other names

Beta-arrestin-1ARRB1ARR1Arrestin beta-1Non-visual arrestin-2Arrestin 2ARB1Beta-arrestin 1Non-visual arrestin 2

Modulation of signaling pathways via GPCR desensitization, Scaffold for MAPK/ERK activation, Regulation of receptor endocytosis and ubiquitination, Modulation of metabolic enzymes (PKM2), Recruitment of transcription co-activators (histone acetyltransferases)