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Target intelligence / Profile preview
Beta-arrestin-2 (ARRB2)
- Target
- ARRB2
- Molecular classification
- Arrestin, Adapter protein, Scaffolding protein
01
Overview
Beta-arrestin-2 (ARRB2) is an intracellular protein that regulates G protein-coupled receptor (GPCR) signaling. It mediates GPCR desensitization and internalization and acts as a scaffold for various signaling cascades, including MAPK pathways. Beta-arrestin-2 is involved in opioid tolerance, inflammation, apoptosis, cardiovascular function, and metabolic regulation, making it a potential therapeutic target.
- Other names
- Arrestin beta-2Beta-arrestin–β-arrestinArrestin beta–β–arrestin
02
Mechanism of action
Scaffolding protein regulating GPCR signaling and downstream pathways. Binds to activated GPCRs preventing G-protein activation and promotes receptor internalization.
03
Biological functions
GPCR desensitizationGPCR resensitizationSignal transductionReceptor traffickingRegulation of MAPK pathways
04
Disease associations
Opioid toleranceInflammationApoptosisHypertensionPeriodontal inflammationCancerMetabolic disordersCentral nervous system disorders
05
Safety considerations
Modulation of opioid tolerancePotential impact on cardiovascular functionInflammation and apoptosis
06
Interacting drugs
Morphine
1 more in the full profile.
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