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Target intelligence / Profile preview
Beta-cardiac myosin heavy chain (β-cardiac myosin)
- Target
- β-cardiac myosin
- Molecular classification
- Motor protein, Myosin, Mechanoenzyme, Actin-binding protein
01
Overview
Beta-cardiac myosin is a molecular motor protein essential for cardiac muscle contraction. Encoded by the MYH7 gene, it converts ATP hydrolysis into mechanical force, driving the shortening of muscle fibers. Mutations in MYH7 are associated with hypertrophic cardiomyopathy, dilated cardiomyopathy, and other inherited cardiac diseases. Small molecules like mavacamten target beta-cardiac myosin to modulate its activity and improve cardiac function.
- Other names
- MYH7Cardiac myosin heavy chain betaMHC-β
02
Mechanism of action
Stabilization of super relaxed state (SRX) of beta-cardiac myosin, reducing excessive contractility
03
Biological functions
Muscle contractionATP hydrolysisForce generationCardiac muscle function
04
Disease associations
Hypertrophic cardiomyopathyDilated cardiomyopathyHeart failureArrhythmia
05
Safety considerations
Variable clinical phenotypes based on mutation locationRisk of heart failureRisk of sudden death
06
Interacting drugs
Mavacamten
07
Biomarkers
MYH7 mutationsLeft ventricular hypertrophy
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