Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Beta-catenin
- Molecular classification
- Catenin protein family, Armadillo repeat superfamily, Transcription factor
01
Overview
Beta-catenin (CTNNB1) is a dual-function protein crucial for cell-cell adhesion and gene transcription regulation. As a key component of adherens junctions, it bridges cadherins to the actin cytoskeleton. In the canonical Wnt signaling pathway, beta-catenin translocates to the nucleus upon pathway activation and interacts with TCF/LEF transcription factors to regulate the expression of Wnt target genes. Its levels are tightly controlled by the destruction complex, and dysregulation leads to pathological accumulation, notably in various cancers.
02
Mechanism of action
Inhibition of beta-catenin degradation; disruption of beta-catenin/TCF/LEF complex; modulation of Wnt signaling pathway
03
Biological functions
Cell adhesionSignal transductionGene transcription regulationWnt signaling pathway regulation
04
Disease associations
CancerColorectal cancerHepatocellular carcinomaLung cancerBreast tumorsOvarian cancerEndometrial cancersMedulloblastomaPilomatrixomaHeart diseaseDilated cardiomyopathyFamilial adenomatous polyposis
05
Safety considerations
Aberrant activation of Wnt signaling can lead to oncogenic transformationPotential for off-target effects due to widespread expression and multiple interaction partners
Beyond the preview
Go deeper on Beta-catenin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Beta-catenin.