Beta-defensin 105B (DEFB105B)

Beta-defensin 105B (DEFB105B) is a small, cationic antimicrobial peptide belonging to the beta-defensin family, which is widely implicated in the innate immune defense of epithelial surfaces against pathogens[1][6][7]. Like other beta-defensins, it is characterized by a structure containing six conserved cysteine residues forming three intramolecular disulfide bonds, giving the peptide a stable β-sheet conformation and amphipathic properties essential for disrupting microbial membranes[2][5]. Beta-defensin 105B exerts broad-spectrum antimicrobial activity, disrupting the membrane integrity of bacteria (both Gram-negative and Gram-positive), fungi, and some enveloped viruses[2][4][7]. The gene encoding Beta-defensin 105B is located on human chromosome 8p23, typically in a duplicated cluster alongside DEFB105A, with both genes producing nearly identical peptides expressed in epithelial tissues[1][6]. Beyond direct microbicidal effects, beta-defensins are recognized for immunomodulatory functions, including the recruitment and activation of immune cells such as dendritic cells, T lymphocytes, and mast cells via chemotactic activity[4][7]. While no drugs currently target this molecule directly, and it is not a classic pharmacological receptor or enzyme, its roles in immune defense and disease make it a protein of interest for infectious and inflammatory disease research[1][4][7]. **Note:** - There is no evidence in current major databases or literature that Beta-defensin 105B (DEFB105B) is misspelled, conceptually incorrect, or an invalid target.[1][6] - No specific drugs are known to target DEFB105B or use it as a biomarker; its therapeutic targeting is primarily theoretical at this time. - Its classification as a “target” is based on its established and broad roles as a direct effector in innate immunity, not as a receptor, enzyme, transporter, or classic drug target.

Other names

Beta-defensin 105DEFB105ABD5DEFB105DEFB5BD-5DEFB-5Beta-defensin 5Defensin, beta 105beta-defensin 105beta-defensin 5defensin, beta 105