Beta-defensin 106A (DEFB106A)

Beta-defensin 106A (DEFB106A) is a small cationic peptide that is part of the human beta-defensin family of antimicrobial peptides. It is encoded by the *DEFB106A* gene, located on chromosome 8p23, in a region with multiple beta-defensin genes[1][5]. The DEFB106A peptide displays broad-spectrum antimicrobial activity against bacteria and fungi, supporting a frontline role in innate immunity—especially at mucosal and epithelial surfaces[1][2][5]. It is expressed in various tissues, notably in the reproductive tract (epididymis, testis), lung, and bone marrow, and participates in the defense of these tissues against infection. In the male reproductive tract, DEFB106A is thought to support proper sperm maturation and reproductive homeostasis. Downregulation of DEFB106A has been observed in some forms of male infertility, implicating it in epididymal health and sperm function. To date, no drugs directly target beta-defensin 106A, and its primary significance is as a component of endogenous host defense rather than a therapeutic target[1][2][5].

Other names

Beta-defensin 106ADEFB106ADEFB106Defensin, beta 106AHuman β-defensin 6

Not applicable. No current drugs utilize beta-defensin 106A as a molecular target. Its mechanism of action as an endogenous peptide involves direct disruption of microbial membranes and innate immune activation[1][2][5].