Beta-defensin 112 (DEFB112)

Beta-defensin 112 (DEFB112) is a member of the beta-defensin family of antimicrobial peptides, which are small, cysteine-rich, cationic molecules predominantly produced by neutrophils and epithelial cells[2][3][5]. Beta-defensins function as part of the innate immune system, providing broad-spectrum antimicrobial activity against bacteria, fungi, and some viruses, largely through direct interaction and disruption of microbial membranes[2][3]. They are also known for their immunomodulatory effects, such as modulating inflammation and recruiting immune cells to sites of infection[1][2]. Beta-defensin 112, like other beta-defensins, is encoded in a cluster of defensin genes and possesses a conserved structural motif that confers stability across various physiological conditions[2]. Research has associated DEFB112 and other beta-defensins with roles in innate host defense, inflammation, and potentially certain infection-related disease states, though DEFB112-specific disease associations remain limited[2]. No drugs are currently known to specifically target DEFB112.

Other names

Beta-defensin 112DEFB112DEFB12DEFB-12Beta-defensin 12Defensin, beta 112defensin, beta 12

Disruption of microbial membranes, Modulation of immune pathways, Inhibition of inflammatory signaling (e.g. NF-κB pathway)