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Target intelligence / Profile preview
Beta-defensin 116 (DEFB116)
- Target
- DEFB116
- Molecular classification
- Antimicrobial peptide, Beta-defensin family, Other
01
Overview
Beta-defensin 116 (DEFB116) is a member of the beta-defensin family of small, cationic antimicrobial peptides involved in innate immunity. These peptides are classified into three groups (alpha, beta, theta) based on their structure, and they are primarily produced by epithelial cells and certain leukocytes. DEFB116 exhibits antibacterial activity, aiding the immune system by disrupting microbial membranes and helping to protect epithelial surfaces from bacterial colonization. There is currently no evidence that DEFB116 is a direct target of therapeutic drugs, nor is it commonly used as a biomarker. Its primary biological function is as an endogenous antimicrobial peptide involved in the defense against infection.
- Other names
- Defensin beta 116DEFB116DEFB16DEFB-16Beta-defensin 16Defensin, beta 116defensin, beta 16beta-defensin 116beta-defensin 16
02
Mechanism of action
Not applicable; not currently a pharmacological target
03
Biological functions
Antibacterial activityInnate immune responseDefense response to bacterium
04
Disease associations
Infection (as part of innate immune defense)Other (potential roles in inflammation)
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