Beta-defensin 130A (DEFB130A)

Beta-defensin 130A (DEFB130A) is a cysteine-rich, cationic antimicrobial peptide important in innate immunity and host defense against microorganisms, including bacteria and parasites. It is a member of the beta-defensin family, found primarily at mucosal surfaces and in some immune cells, and functions by disrupting negatively charged microbial membranes, leading to cell lysis. DEFB130A also shows immunomodulatory effects and has been reported to possess direct antiplasmodial activity, suggesting a broader role in innate defense. Beta-defensin 130A is a secreted, antimicrobial peptide that plays a critical role in innate immunity by targeting invading microorganisms. It is not a receptor, enzyme, or other therapeutic target as typically defined in pharmacology, and there is no evidence for direct drug interaction, biomarker use, or specific safety issues related to drug development. It operates primarily by disrupting the membranes of pathogens and modulating immune responses.

Other names

Beta-defensin 130ADEFB130ADEFB130DEFB30DEFB-30Beta-defensin 130Beta-defensin 30Defensin, beta 130DEFB130Lbeta-defensin 130defensin beta 130defensin, beta 30