Beta-defensin 135 (DEFB135)

Beta-defensin 135 (DEFB135) is a small, cationic, cysteine-rich peptide and member of the beta-defensin family, most well characterized in mammals such as cattle, but not well annotated in humans[1]. Beta-defensins are key components of the innate immune system, serving as broad-spectrum antimicrobial peptides that disrupt microbial membranes and contribute to immune defense against bacteria, viruses, and fungi[1][2][3]. Their structure is stabilized by three conserved intramolecular disulfide bonds formed by six cysteines. Beta-defensins also exhibit immunomodulatory functions such as chemotactic activity for immune cells, regulation of inflammation, and contributions to epithelial barrier defense and reproductive functions[1][2][3]. However, DEFB135 itself is poorly studied and lacks characterization regarding expression, function, and disease relevance, with information often conflated with other closely related beta-defensin family members. DEFB135 is not documented as a druggable target, biomarker, or known modulator for human disease[1][2][3]. If further species-specific clarification or functional information emerges regarding DEFB135 in future research, molecular classification and disease associations would need to be revisited using curated protein or gene databases and peer-reviewed literature.

Other names

Beta-defensin 135DEFB135Defensin, beta 135DEFB136Beta-defensin 136

Not applicable. There are no drugs targeting DEFB135, thus no known mechanism of action in a therapeutic context[3].