Beta-enolase (ENO3)

Beta-enolase (ENO3) is an enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and is predominantly expressed in adult skeletal and cardiac muscle. It is crucial for energy metabolism, muscle differentiation, development, and regeneration. Mutations in the ENO3 gene cause glycogen storage disease type XIII and are associated with impaired energy production, which can contribute to muscle weakness, exercise intolerance, and cardiac dysfunction. The protein works both as a key metabolic enzyme and as a participant in muscle structure and regulatory protein networks. While ENO3 itself is not a current direct therapeutic target, its role in metabolic and muscle diseases makes it of substantial biomedical interest[2][3][4][1].

Other names

Beta-enolasemuscle-specific enolaseskeletal muscle enolasemuscle enriched enolase2-phospho-D-glycerate hydro-lyaseEnolase 3MSEGSD13enolase 3 (beta, muscle)ENOBENO3muscle enolase[2][3]

Not directly drug-targeted in clinical use. For related isoenzymes/inhibitors, action would be glycolytic inhibition, leading to reduced ATP production in target muscle cells.