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Target intelligence / Profile preview
Beta-glucocerebrosidase (GCase)
- Target
- GCase
- Molecular classification
- Enzyme, Glycosyl hydrolase
01
Overview
Beta-glucocerebrosidase (GCase) is a lysosomal enzyme responsible for the hydrolysis of glucocerebroside into glucose and ceramide. It is essential for cellular lipid metabolism and membrane recycling. Mutations in the GBA gene, encoding GCase, cause Gaucher disease and increase the risk of Parkinson's disease. Therapeutic strategies include enzyme replacement therapy.
- Other names
- Acid β-glucosidaseD-glucosyl-N-acylsphingosine glucohydrolase
02
Mechanism of action
Enzyme replacement therapy
03
Biological functions
Membrane lipid recyclingSkin barrier formationHydrolysis of glucocerebroside
04
Disease associations
Gaucher DiseaseParkinson’s Disease
05
Safety considerations
ImmunogenicityInfusion reactionsBlood-brain barrier penetration (for neurological symptoms)
06
Interacting drugs
Imiglucerase
07
Biomarkers
Glucocerebroside levelsBeta-glucocerebrosidase activity
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