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Target intelligence / Profile preview
Beta-glucosidase 2 (GBA2)
- Target
- GBA2
- Molecular classification
- Enzyme, Glycoside hydrolase family GH116
01
Overview
Beta-glucosidase 2 (GBA2) is a non-lysosomal enzyme that catalyzes the hydrolysis of glucosylceramide, a membrane lipid, into glucose and ceramide. This reaction is crucial for the metabolism of glycosphingolipids on the cytoplasmic face of cellular membranes. Mutations in the GBA2 gene are associated with genetic neurological disorders such as hereditary spastic paraplegia and cerebellar ataxia, highlighting its importance in nervous system function. It belongs to the Glycoside hydrolase family GH116, distinct from lysosomal glucocerebrosidase/GBA which belongs to GH30.
02
Mechanism of action
Hydrolyzes glucosylceramide into glucose and ceramide using a double-displacement mechanism.
03
Biological functions
Sphingolipid metabolismGlycolipid metabolismHydrolysis of glucosylceramide
04
Disease associations
Hereditary spastic paraplegiaCerebellar ataxiaNeurological disorders
05
Interacting drugs
N-butyldeoxygalactonojirimycin
2 more in the full profile.
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