Beta-glucosidase from Agrobacterium faecalis (None established; commonly referred to as "β-glucosidase" or "Abg" in literature)

Beta-glucosidase from Agrobacterium faecalis is an enzyme that catalyzes the hydrolysis of β-glucosidic bonds in various glucosides, including cellobiose and aryl glucosides, facilitating the release of glucose. It belongs to glycosyl hydrolase family 1 and exhibits a broad specificity for different substrates. Its enzymatic mechanism involves a two-step hydrolysis with formation of a glucosyl-enzyme intermediate, characteristic of retaining glycosidases. This enzyme plays key roles in microbial degradation of cellulose and organic matter in the environment, plant-microbe interactions, and basic research on enzyme mechanisms. This enzyme is primarily of interest for biochemical, ecological, and industrial applications, rather than as a direct human therapeutic target.

Other names

Beta-glucosidase from Agrobacterium faecalisAbg (used in mechanistic/biochemical literature)(Previously) Beta-glucosidase from Alcaligenes faecalis

Hydrolyzes β-glucosidic bonds via a two-step mechanism involving a glucosyl-enzyme intermediate and oxocarbenium ion-like transition states. Inhibitors such as cyclophellitol bind to the active site and inactivate the enzyme by covalently modifying the catalytic nucleophile.