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Target intelligence / Profile preview
Beta-ketoacyl-acyl carrier protein synthase
- Molecular classification
- Enzyme
01
Overview
Beta-ketoacyl-acyl carrier protein (ACP) synthase is a key enzyme in the fatty acid biosynthesis pathway, catalyzing the condensation reactions that elongate fatty acid chains. There are several isoforms, including KAS I (FabB), KAS II (FabF), and KAS III (FabH). KAS III (FabH) is particularly important as it initiates the first elongation step in type II fatty acid synthesis found in bacteria and plant plastids. It is considered a drug target for developing antimicrobial agents.
- Other names
- Beta-ketoacyl ACP synthaseKAS IKAS IIKAS IIIFabBFabFFabH
02
Mechanism of action
Inhibition of beta-ketoacyl-ACP synthase activity
03
Biological functions
Fatty acid biosynthesisLipid metabolism
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects if inhibitors are not highly specific.
06
Interacting drugs
Thiolactomycin
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