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Target intelligence / Profile preview
Beta-Klotho (KLB)
- Target
- KLB
- Molecular classification
- Type-I single-pass transmembrane protein, Receptor, Coreceptor
01
Overview
Beta-Klotho (β-Klotho, KLB) is an essential type-I single-pass transmembrane protein acting as a coreceptor for endocrine fibroblast growth factors, primarily FGF19 and FGF21. It is crucial for FGF19 and FGF21 signaling in metabolic tissues like the liver, adipose tissue, and pancreas, influencing energy homeostasis, glucose/lipid metabolism, and insulin sensitivity. It has also been implicated in tumor suppression.
- Other names
- β-KlothoKLB
02
Mechanism of action
Forms ternary complexes with FGFRs upon binding FGF19 or FGF21, enabling high-affinity binding and downstream signaling.
03
Biological functions
Signal transductionRegulation of energy homeostasisRegulation of glucose metabolismRegulation of lipid metabolismRegulation of insulin sensitivityModulation of growth factor signaling pathways
04
Disease associations
Metabolic disordersObesityDiabetesCancer
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