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Target intelligence / Profile preview
Beta-Klotho Co-receptor (KLB)
- Target
- KLB
- Molecular classification
- Single-pass transmembrane glycoprotein, Receptor, Co-receptor
01
Overview
Beta-Klotho (KLB) is a type I single-pass transmembrane glycoprotein and an essential co-receptor in the fibroblast growth factor (FGF) signaling pathway, particularly for endocrine FGFs such as FGF19, FGF21, and FGF15. It forms heterodimeric complexes with specific fibroblast growth factor receptors (FGFRs), notably FGFR1c and FGFR4. Beta-Klotho is central to metabolic homeostasis, regulating carbohydrate and lipid metabolism, bile acid homeostasis and demonstrating anti-inflammatory action in the liver. Dysfunction leads to metabolic dysregulation and liver function disturbances.
- Other names
- KLB proteinBeta-Klotho
02
Mechanism of action
Modulation of beta-Klotho or its ligand interactions for therapeutic effect.
03
Biological functions
FGF receptor signalingGlucose metabolism regulationLipid metabolism regulationBile acid homeostasisEnergy expenditure regulationHepatic anti-inflammatory action
04
Disease associations
ObesityDiabetes mellitus type IINon-alcoholic fatty liver disease (NAFLD)Cholestatic disordersMetabolic dysregulation
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